{"id":395,"date":"2023-08-04T03:40:11","date_gmt":"2023-08-04T03:40:11","guid":{"rendered":"https:\/\/calerie-energysystem.info\/?p=395"},"modified":"2023-08-04T03:57:59","modified_gmt":"2023-08-04T03:57:59","slug":"nrf2-mot-chia-khoa-quan-trong-trong-co-the","status":"publish","type":"post","link":"https:\/\/calerievn.com\/index.php\/2023\/08\/04\/nrf2-mot-chia-khoa-quan-trong-trong-co-the\/","title":{"rendered":"NRF2 m\u1ed9t ch\u00eca kh\u00f3a quan tr\u1ecdng trong c\u01a1 th\u1ec3"},"content":{"rendered":"

Gi\u1edbi thi\u1ec7u v\u1ec1 Nrf2<\/span><\/strong><\/h3>\n

Nrf2 l\u00e0 m\u1ed9t lo\u1ea1i protein c\u00f3 trong m\u1ecdi t\u1ebf b\u00e0o c\u1ee7a c\u01a1 th\u1ec3, gi\u00fap g\u1eedi th\u00f4ng tin \u0111\u1ebfn c\u00e1c DNA c\u1ee7a t\u1ebf b\u00e0o. M\u1ed9t khi Nrf2 \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t, n\u00f3 s\u1ebd ph\u00e1t ra t\u00edn hi\u1ec7u \u0111\u1ebfn h\u00e0ng tr\u0103m m\u00e3 gen c\u00f2n \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 gen sinh t\u1ed3n. Sau \u0111\u00f3, nh\u1eefng gen n\u00e0y s\u1ebd gi\u00fap cho c\u00e1c t\u1ebf b\u00e0o s\u1ed1ng s\u00f3t khi \u0111\u1ed1i m\u1eb7t v\u1edbi c\u00e1c lo\u1ea1i \u0111\u1ed9c t\u1ed1 kh\u00e1c nhau, trong \u0111\u00f3 nguy hi\u1ec3m nh\u1ea5t c\u00f3 th\u1ec3 k\u1ec3 \u0111\u1ebfn stress oxy h\u00f3a.<\/span><\/p>\n

Protein NRF2 \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn nh\u01b0 l\u00e0 m\u1ed9t ch\u1ea5t truy\u1ec1n tin protein t\u1ef1 li\u00ean k\u1ebft v\u1edbi DNA, c\u00f3 kh\u1ea3 n\u0103ng \u0111i v\u00e0o t\u1eadn nh\u00e2n t\u1ebf b\u00e0o, n\u00f3 k\u00edch ho\u1ea1t\u00a0ti th\u1ec3 c\u1ee7a t\u1ebf b\u00e0o gi\u00fap cho t\u1ebf\u00a0b\u00e0o t\u1ef1 s\u1ea3n sinh\u00a0ra kh\u00e1ng th\u1ec3, s\u1ea3n sinh ra n\u0103ng l\u01b0\u1ee3ng \u0111\u1ec3 t\u1ebf\u00a0b\u00e0o t\u1ef1 s\u1eeda ch\u1eefa v\u00e0 c\u00f3 t\u00e1c d\u1ee5ng s\u1eeda ch\u1eefa cho\u00a0ch\u00ednh c\u01a1 th\u1ec3.<\/span><\/p>\n

Protein NRF2 khi \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t s\u1ebd s\u1ea3n sinh ra ch\u1ea5t ch\u1ed1ng\u00a0oxy h\u00f3a n\u1ed9i sinh, enzym n\u1ed9i sinh nh\u01b0: enzym SOD, enzym calatosa\u2026.<\/span><\/p>\n

Protein NRF2 k\u00edch ho\u1ea1t \u0111\u01b0\u1ee3c Glutathion, ch\u1ea5t c\u00f3 kh\u1ea3 n\u0103ng x\u1eed l\u00fd OH\u2013\u00a0<\/sup>do \u0111\u00f3 x\u1eed l\u00fd \u0111\u01b0\u1ee3c qu\u00e1 tr\u00ecnh oxy h\u00f3a, lo\u1ea1i tr\u1eeb c\u00e1c c\u00e1c g\u1ed1c t\u1ef1 do, b\u1ea3o v\u1ec7 c\u01a1 th\u1ec3 tr\u00e1nh kh\u1ecfi b\u1ec7nh t\u1eadt v\u00e0 l\u00e3o h\u00f3a.<\/span><\/p>\n

Nh\u1eefng l\u1ee3i \u00edch c\u1ee7a Nrf2 \u0111\u1ed1i v\u1edbi s\u1ee9c kh\u1ecfe<\/span><\/strong><\/h3>\n

Nrf2 ch\u1ed1ng l\u1ea1i \u0111\u1ed9c t\u1ed1<\/span><\/strong><\/h4>\n

C\u01a1 th\u1ec3 con ng\u01b0\u1eddi c\u00f3 th\u1ec3 t\u1ed3n t\u1ea1i r\u1ea5t nhi\u1ec1u nh\u1eefng h\u1ee3p ch\u1ea5t c\u00f3 h\u1ea1i, v\u00e0 m\u00f4i tr\u01b0\u1eddng xung quanh c\u0169ng t\u1ed3n t\u1ea1i m\u1ed9t l\u01b0\u1ee3ng \u0111\u00e1ng k\u1ec3. Nrf2 l\u00e0 m\u1ed9t ch\u1ea5t n\u1ed9i t\u1ea1i \u0111\u1eb7c bi\u1ec7t c\u00f3 th\u1ec3 b\u1ea3o v\u1ec7 c\u00e1c t\u1ebf b\u00e0o kh\u1ecfi s\u1ef1 t\u00e1c \u0111\u1ed9ng ti\u00eau c\u1ef1c do c\u00e1c ch\u1ea5t \u0111\u1ed9c h\u1ea1i.<\/span><\/p>\n

Khi Nrf2 \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t, ph\u1ea3n \u1ee9ng c\u1ee7a c\u01a1 th\u1ec3 \u0111\u1ed1i v\u1edbi c\u00e1c lo\u1ea1i \u0111\u1ed9c t\u1ed1 v\u00e0 thu\u1ed1c s\u1ebd m\u1ea1nh m\u1ebd h\u01a1n. \u0110\u1ed3ng th\u1eddi, Nrf2 c\u00f2n gi\u00fap c\u1ea3i thi\u1ec7n vi\u1ec7c s\u1ea3n xu\u1ea5t ra c\u00e1c protein \u0111\u1ec3 gi\u00fap lo\u1ea1i b\u1ecf \u0111i c\u00e1c r\u00e1c th\u1ea3i kh\u1ecfi t\u1ebf b\u00e0o. V\u00ed d\u1ee5: khi c\u01a1 th\u1ec3 ch\u00fang ta h\u00edt ph\u1ea3i kh\u00f3i thu\u1ed1c l\u00e1, th\u00e0nh ph\u1ea7n Nrf2 s\u1ebd \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t, t\u1eeb \u0111\u00f3 cho ph\u00e9p ph\u1ed5i th\u1ef1c hi\u1ec7n gi\u1ea3i \u0111\u1ed9c.<\/span><\/p>\n

Khi b\u1ed5 sung Nrf2 v\u00e0o c\u01a1 th\u1ec3, c\u00e1c chuy\u00ean gia c\u0169ng nh\u1eadn \u0111\u1ecbnh v\u1ec1 kh\u1ea3 n\u0103ng ph\u1ed5i s\u1ebd t\u1ef1 b\u1ea3o v\u1ec7 \u0111\u1ec3 ch\u1ed1ng l\u1ea1i n\u1ed9i \u0111\u1ed9c t\u1ed1 do vi khu\u1ea9n g\u00e2y ra, c\u00e1c ch\u1ea5t g\u00e2y d\u1ecb \u1ee9ng, c\u00e1c b\u1ec7nh do virus, c\u00e1c ch\u1ea5t g\u00e2y n\u00ean \u00f4 nhi\u1ec5m m\u00f4i tr\u01b0\u1eddng kh\u00e1c, hyperoxia (ng\u1ed9 \u0111\u1ed9c oxy).<\/span><\/p>\n

B\u00ean c\u1ea1nh \u0111\u00f3, Nrf2 t\u1ed3n t\u1ea1i b\u00ean trong c\u01a1 th\u1ec3 c\u0169ng s\u1ebd gi\u00fap b\u1ea3o v\u1ec7 ch\u1ee9c n\u0103ng gan kh\u1ecfi t\u00e1c h\u1ea1i t\u1eeb \u0111\u1ed9c t\u00ednh. Th\u1eadm ch\u00ed, Nrf2 c\u0169ng c\u00f3 th\u1ec3 b\u1ea3o v\u1ec7 gan kh\u1ecfi vi\u1ec7c nhi\u1ec5m \u0111\u1ed9c gan asen.<\/span><\/p>\n

Nrf2 khi ch\u1ed1ng vi\u00eam<\/span><\/strong><\/h4>\n

C\u01a1 th\u1ec3 s\u1ebd n\u1ea3y sinh ph\u1ea3n \u1ee9ng b\u1ea3o v\u1ec7 b\u00ecnh th\u01b0\u1eddng tr\u01b0\u1edbc c\u00e1c t\u1ed5n th\u01b0\u01a1ng g\u00e2y ra, t\u00ecnh tr\u1ea1ng n\u00e0y \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 vi\u00eam. Khi Nrf2 \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t, ch\u00fang c\u00f3 th\u1ec3 ho\u1ea1t \u0111\u1ed9ng \u0111\u1ec3 ch\u1ed1ng l\u1ea1i t\u00ecnh tr\u1ea1ng vi\u00eam g\u00e2y ra b\u1eb1ng c\u00e1ch gi\u1ea3m \u0111i cytokine l\u00e0 t\u00e1c nh\u00e2n g\u00e2y vi\u00eam.<\/span><\/p>\n

B\u00ean c\u1ea1nh \u0111\u00f3, Nrf2 c\u0169ng c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m vi\u00eam c\u00f9ng v\u1edbi c\u00e1c v\u1ea5n \u0111\u1ec1 s\u1ee9c kh\u1ecfe nan gi\u1ea3i kh\u00e1c nh\u01b0 x\u01a1 h\u00f3a gan, th\u1eadn, ph\u1ed5i, vi\u00eam kh\u1edbp. Nh\u1eafc \u0111\u1ebfn l\u1ee3i \u00edch c\u1ee7a Nrf2 khi ch\u1ed1ng vi\u00eam, \u0111\u1eb7c bi\u1ec7t kh\u00f4ng th\u1ec3 kh\u00f4ng nh\u1eafc \u0111\u1ebfn vi\u1ec7c ki\u1ec3m so\u00e1t d\u1ecb \u1ee9ng b\u1eb1ng c\u00e1ch gi\u1ea3m \u0111i c\u00e1c cytokine Th1\/ Th17 v\u00e0 l\u00e0m t\u0103ng l\u00ean c\u00e1c cytokine Th2. B\u1ec7nh hen suy\u1ec5n s\u1ebd \u0111\u01b0\u1ee3c gi\u1ea3m thi\u1ec3u nh\u1edd v\u00e0o t\u00e1c d\u1ee5ng n\u00e0y.<\/span><\/p>\n

Nrf2 gi\u00fap t\u0103ng c\u01b0\u1eddng ch\u1ee9c n\u0103ng ti th\u1ec3<\/span><\/strong><\/h4>\n

Ti th\u1ec3 t\u1ed3n t\u1ea1i v\u1edbi ch\u1ee9c n\u0103ng ch\u1ee7 y\u1ebfu l\u00e0 chuy\u1ec3n h\u00f3a n\u0103ng l\u01b0\u1ee3ng, l\u01b0u tr\u1eef ion canxi, \u0111\u00f3ng vai tr\u00f2 trung t\u00e2m trong ti\u1ebfn tr\u00ecnh trao \u0111\u1ed5i ch\u1ea5t\u2026 Khi Nrf2 \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t, n\u0103ng l\u01b0\u1ee3ng ATP cho ti l\u1ea1p th\u1ec3 s\u1ebd t\u0103ng l\u00ean. N\u1ebfu kh\u00f4ng c\u00f3 s\u1ef1 h\u1ed7 tr\u1ee3 c\u1ee7a Nrf2, ti th\u1ec3 s\u1ebd ch\u1ec9 c\u00f3 kh\u1ea3 n\u0103ng ho\u1ea1t \u0111\u1ed9ng v\u1edbi glucose ho\u1eb7c \u0111\u01b0\u1eddng. V\u00e0 khi c\u00f3 s\u1ef1 h\u1ed7 tr\u1ee3 t\u1eeb Nrf2, ti th\u1ec3 s\u1ebd c\u00f3 kh\u1ea3 n\u0103ng ho\u1ea1t \u0111\u1ed9ng v\u1edbi ch\u1ea5t b\u00e9o.<\/span><\/p>\n

C\u00e1c l\u1ee3i \u00edch kh\u00e1c \u0111\u1ed1i v\u1edbi c\u01a1 th\u1ec3<\/span><\/strong><\/h4>\n

Ngo\u00e0i nh\u1eefng l\u1ee3i \u00edch n\u1ed5i b\u1eadt m\u00e0 Nrf2 mang \u0111\u1ebfn cho c\u01a1 th\u1ec3 nh\u01b0 tr\u00ean th\u00ec c\u00f2n r\u1ea5t nhi\u1ec1u nh\u1eefng l\u1ee3i \u00edch kh\u00e1c \u0111\u01b0\u1ee3c ghi nh\u1eadn hi\u1ec7u qu\u1ea3 khi Nrf2 \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t: Gi\u00fap ch\u1ed1ng l\u1ea1i stress oxy h\u00f3a, Gi\u00fap \u0111\u1ea9y l\u00f9i t\u00ecnh tr\u1ea1ng l\u00e3o h\u00f3a ng\u00e0y m\u1ed9t di\u1ec5n ra m\u1ea1nh m\u1ebd \u1edf c\u01a1 th\u1ec3, T\u0103ng hi\u1ec7u su\u1ea5t khi t\u1eadp th\u1ec3 d\u1ee5c r\u00e8n luy\u1ec7n c\u01a1 th\u1ec3, B\u1ea3o v\u1ec7 c\u01a1 th\u1ec3 v\u00e0 ch\u1ed1ng l\u1ea1i t\u00ecnh tr\u1ea1ng thi\u1ebfu oxy, \u00a0T\u0103ng c\u01b0\u1eddng h\u1ec7 th\u1ed1ng m\u1ea1ch m\u00e1u, Gi\u1ea3m t\u00ecnh tr\u1ea1ng tr\u1ea7m c\u1ea3m, B\u1ea3o v\u1ec7 c\u00e1c c\u01a1 quan t\u00ecnh d\u1ee5c (gi\u1eef cho tinh tr\u00f9ng kh\u00f4ng b\u1ecb t\u1ed5n h\u1ea1i), t\u0103ng c\u01b0\u1eddng ch\u1ee9c n\u0103ng t\u00ecnh d\u1ee5c, c\u1ea3i thi\u1ec7n ham mu\u1ed1n t\u00ecnh d\u1ee5c, T\u0103ng c\u01b0\u1eddng tr\u00ed nh\u1edb, ng\u0103n ng\u1eeba v\u00e0 ph\u00f2ng b\u1ec7nh Alheimer.<\/span><\/p>\n

S\u1ea3n ph\u1ea9m Alpha hope l\u00e0 m\u1ed9t trong nh\u1eefng s\u1ea3n ph\u1ea9m gi\u00fap c\u01a1 th\u1ec3 k\u00edch ho\u1ea1t \u0111\u01b0\u1ee3c Nrf2 trong c\u01a1 th\u1ec3, xem th\u00eam v\u1ec1 Alphahope<\/a><\/p>\n

\"anpha<\/p>\n","protected":false},"excerpt":{"rendered":"

Gi\u1edbi thi\u1ec7u v\u1ec1 Nrf2 Nrf2 l\u00e0 m\u1ed9t lo\u1ea1i protein c\u00f3 trong m\u1ecdi t\u1ebf b\u00e0o c\u1ee7a c\u01a1 th\u1ec3, gi\u00fap g\u1eedi th\u00f4ng tin \u0111\u1ebfn c\u00e1c DNA c\u1ee7a t\u1ebf b\u00e0o. M\u1ed9t khi Nrf2 \u0111\u01b0\u1ee3c k\u00edch…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,6,5],"tags":[],"class_list":["post-395","post","type-post","status-publish","format-standard","hentry","category-alpha-hope","category-lam-dep","category-suc-khoe"],"yoast_head":"\nNRF2 m\u1ed9t ch\u00eca kh\u00f3a quan tr\u1ecdng trong c\u01a1 th\u1ec3 - Ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe b\u1eaft \u0111\u1ea7u t\u1eeb t\u1ebf b\u00e0o<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/calerievn.com\/index.php\/2023\/08\/04\/nrf2-mot-chia-khoa-quan-trong-trong-co-the\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NRF2 m\u1ed9t ch\u00eca kh\u00f3a quan tr\u1ecdng trong c\u01a1 th\u1ec3 - Ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe b\u1eaft \u0111\u1ea7u t\u1eeb t\u1ebf b\u00e0o\" \/>\n<meta property=\"og:description\" content=\"Gi\u1edbi thi\u1ec7u v\u1ec1 Nrf2 Nrf2 l\u00e0 m\u1ed9t lo\u1ea1i protein c\u00f3 trong m\u1ecdi t\u1ebf b\u00e0o c\u1ee7a c\u01a1 th\u1ec3, gi\u00fap g\u1eedi th\u00f4ng tin \u0111\u1ebfn c\u00e1c DNA c\u1ee7a t\u1ebf b\u00e0o. 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