{"id":420,"date":"2023-08-06T00:50:16","date_gmt":"2023-08-06T00:50:16","guid":{"rendered":"https:\/\/calerie-energysystem.info\/?p=420"},"modified":"2024-12-17T15:07:50","modified_gmt":"2024-12-17T15:07:50","slug":"sod-la-gi","status":"publish","type":"post","link":"https:\/\/calerievn.com\/index.php\/2023\/08\/06\/sod-la-gi\/","title":{"rendered":"SOD l\u00e0 g\u00ec?"},"content":{"rendered":"

SOD l\u00e0 m\u1ed9t lo\u1ea1i Enzym ch\u1ed1ng oxy h\u00f3a c\u00f3 trong t\u1ea5t c\u1ea3 c\u00e1c t\u1ebf b\u00e0o s\u1ed1ng trong c\u01a1 th\u1ec3. N\u00f3 \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c gi\u1ea3m stress oxy h\u00f3a.\u00a0<\/span>SOD c\u00f3 vai tr\u00f2 ch\u00ednh trong vi\u1ec7c ch\u1ed1ng l\u1ea1i t\u1ed5n th\u01b0\u01a1ng v\u00e0 vi\u00eam do g\u1ed1c t\u1ef1 do. SOD l\u00e0 ch\u1ea5t ch\u1ed1ng vi\u00eam trong c\u00e1c t\u00ecnh tr\u1ea1ng vi\u00eam c\u1ea5p t\u00ednh v\u00e0 m\u00e3n t\u00ednh, <\/span>Enzym SOD l\u00e0 x\u00fac t\u00e1c qu\u00e1 tr\u00ecnh chuy\u1ec3n \u0111\u1ed5i ch\u1ea5t oxy h\u00f3a th\u00e0nh <\/span>H2<\/sub>O2<\/sub><\/span><\/p>\n

TI\u1ec0M N\u0102NG TR\u1eca LI\u1ec6U C\u1ee6A SOD<\/strong><\/span><\/h2>\n

Trong m\u1ed9t nghi\u00ean c\u1ee9u c\u1ee7a <\/strong>H. Younus\u201cTherapeutic potentials of superoxide dismutase\u201d \u0111\u01b0\u1ee3c \u0111\u0103ng t\u1ea3i trong t\u1ea1p ch\u00ed International Journal of Health Sciences: <\/strong>Int J Health Sci (Qassim), 2018 May-Jun;12(3): 88-93. \u0111\u1ec1 c\u1eadp \u0111\u1ebfn ti\u1ec1m n\u0103ng tr\u1ecb li\u1ec7u c\u1ee7a SOD nh\u01b0 sau: https:\/\/drive.google.com\/file\/d\/1ErT4fTpCsq-yj0XDtn4V38ViFVauqED7\/view?usp=drive_link<\/a><\/span><\/p>\n

Ti\u1ec1m n\u0103ng tr\u1ecb li\u1ec7u c\u1ee7a Superoxide Dismutase<\/span><\/p>\n

Superoxide dismutases (SODs) t\u1ea1o th\u00e0nh m\u1ed9t ch\u1ea5t b\u1ea3o v\u1ec7 ch\u1ed1ng oxy h\u00f3a r\u1ea5t quan tr\u1ecdng ch\u1ed1ng l\u1ea1i stress oxy h\u00f3a trong c\u01a1 th\u1ec3. Enzyme ho\u1ea1t \u0111\u1ed9ng nh\u01b0 m\u1ed9t t\u00e1c nh\u00e2n \u0111i\u1ec1u tr\u1ecb t\u1ed1t ch\u1ed1ng l\u1ea1i c\u00e1c b\u1ec7nh do oxy h\u00f3a.<\/span><\/p>\n

B\u00e0i n\u00e0y m\u00f4 t\u1ea3 t\u00e1c d\u1ee5ng tr\u1ecb li\u1ec7u c\u1ee7a SOD trong c\u00e1c t\u00ecnh tr\u1ea1ng b\u1ec7nh l\u00fd v\u00e0 sinh l\u00fd kh\u00e1c nhau nh\u01b0 ung th\u01b0, b\u1ec7nh vi\u00eam nhi\u1ec5m, x\u01a1 nang, thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9, l\u00e3o h\u00f3a, vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p, b\u1ec7nh tho\u00e1i h\u00f3a th\u1ea7n kinh v\u00e0 b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng.<\/span><\/p>\n

1. SOD v\u00e0 ung th\u01b0<\/strong><\/span><\/h3>\n

Nhi\u1ec1u nghi\u00ean c\u1ee9u \u0111\u00e3 ti\u1ebft l\u1ed9 vai tr\u00f2 quan tr\u1ecdng c\u1ee7a stress oxy h\u00f3a trong qu\u00e1 tr\u00ecnh sinh ung th\u01b0. C\u00f3 m\u1ed9t s\u1ed1 b\u1eb1ng ch\u1ee9ng r\u00f5 r\u00e0ng ch\u1ec9 ra r\u1eb1ng ROS ho\u1ea1t \u0111\u1ed9ng nh\u01b0 m\u1ed9t l\u1edbp ch\u1ea5t g\u00e2y ung th\u01b0 n\u1ed9i sinh b\u1eb1ng c\u00e1ch g\u00e2y ra c\u00e1c \u0111\u1ed9t bi\u1ebfn trong t\u1ebf b\u00e0o. L\u00e0m gi\u1ea3m ho\u1ea1t \u0111\u1ed9ng c\u1ee7a Cu-SOD, Zn-SOD v\u00e0 Mn-SOD\u00a0 trong c\u00e1c t\u1ebf b\u00e0o ung th\u01b0.<\/span><\/p>\n

” ROS (Reactive Oxygen Species) l\u00e0 nh\u1eefng ph\u00e2n t\u1eed oxy ho\u1ea1t t\u00ednh, \u0111\u01b0\u1ee3c t\u1ea1o ra trong qu\u00e1 tr\u00ecnh chuy\u1ec3n \u0111\u1ed5i oxy h\u00f3a trong c\u01a1 th\u1ec3. N\u00f3 c\u00f3 vai tr\u00f2 quan tr\u1ecdng trong c\u00e1c qu\u00e1 tr\u00ecnh sinh h\u00f3a v\u00e0 t\u1ebf b\u00e0o nh\u01b0ng c\u0169ng c\u00f3 th\u1ec3 g\u00e2y h\u1ea1i n\u1ebfu c\u00f3 qu\u00e1 nhi\u1ec1u. <\/em><\/span>Khi c\u01a1 th\u1ec3 s\u1ea3n xu\u1ea5t ROS qu\u00e1 m\u1ee9c ho\u1eb7c kh\u00f4ng th\u1ec3 lo\u1ea1i b\u1ecf ch\u00fang \u0111\u1ee7 nhanh, s\u1ef1 c\u00e2n b\u1eb1ng gi\u1eefa ROS v\u00e0 ch\u1ea5t ch\u1ed1ng oxi h\u00f3a s\u1ebd b\u1ecb ph\u00e1 v\u1ee1. \u0110i\u1ec1u n\u00e0y g\u00e2y ra hi\u1ec7n t\u01b0\u1ee3ng g\u1ecdi l\u00e0 stress oxi h\u00f3a, l\u00e0 m\u1ed9t nguy\u00ean nh\u00e2n ch\u00ednh g\u00e2y ra nhi\u1ec1u b\u1ec7nh l\u00fd trong y h\u1ecdc.<\/em><\/span><\/p>\n

ROS c\u00f3 th\u1ec3 g\u00e2y t\u1ed5n th\u01b0\u01a1ng t\u1ebf b\u00e0o v\u00e0 t\u00e1c \u0111\u1ed9ng ti\u00eau c\u1ef1c \u0111\u1ebfn c\u00e1c th\u00e0nh ph\u1ea7n c\u1ea5u tr\u00fac c\u1ee7a t\u1ebf b\u00e0o, nh\u01b0 DNA, protein v\u00e0 lipid. Ch\u00fang t\u00e1c \u0111\u1ed9ng v\u00e0o c\u00e1c qu\u00e1 tr\u00ecnh nh\u01b0 s\u1ef1 t\u1ed5 h\u1ee3p v\u00e0 ph\u00e2n t\u00e1ch c\u1ee7a c\u00e1c ph\u00e2n t\u1eed, l\u00e0m thay \u0111\u1ed5i c\u1ea5u tr\u00fac v\u00e0 ch\u1ee9c n\u0103ng c\u1ee7a ch\u00fang. N\u1ebfu kh\u00f4ng ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c l\u01b0\u1ee3ng ROS, t\u1ebf b\u00e0o s\u1ebd b\u1ecb t\u1ed5n th\u01b0\u01a1ng v\u00e0 d\u1eabn \u0111\u1ebfn c\u00e1c v\u1ea5n \u0111\u1ec1 s\u1ee9c kh\u1ecfe nghi\u00eam tr\u1ecdng nh\u01b0 ung th\u01b0, b\u1ec7nh tim m\u1ea1ch, vi\u00eam nhi\u1ec5m v\u00e0 l\u00e3o h\u00f3a.”<\/em><\/span><\/p>\n

Vi\u1ec7c \u1ed5n \u0111\u1ecbnh m\u1ee9c \u0111\u1ed9 SOD g\u00f3p ph\u1ea7n v\u00e0o s\u1ef1 \u0111\u1ea3o ng\u01b0\u1ee3c ki\u1ec3u h\u00ecnh t\u1ebf b\u00e0o ung th\u01b0. Ng\u01b0\u1eddi ta \u0111\u00e3 g\u1ee3i \u00fd r\u1eb1ng SOD c\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh s\u1ef1 ti\u1ebfn tri\u1ec3n c\u1ee7a ung th\u01b0 v\u00e0 do \u0111\u00f3, c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng nh\u01b0 m\u1ed9t m\u1ee5c ti\u00eau m\u1edbi \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0.<\/span><\/p>\n

H\u01a1n n\u1eefa, ng\u01b0\u1eddi ta \u0111\u00e3 ch\u1ee9ng minh r\u1eb1ng Cu-SOD, Zn-SOD c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng nh\u01b0 m\u1ed9t m\u1ee5c ti\u00eau \u0111i\u1ec1u tr\u1ecb m\u1edbi \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb \u0111au t\u1ee7y.<\/span><\/p>\n

SOD liposome\/mimetics \u0111\u00e3 th\u1ef1c nghi\u1ec7m cho th\u1ea5y k\u1ebft qu\u1ea3 \u0111\u1ea7y h\u1ee9a h\u1eb9n trong c\u00e1c m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt ph\u00f2ng ch\u1ed1ng ung th\u01b0. Ch\u00fang c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 an to\u00e0n trong giai \u0111o\u1ea1n \u0111\u1ea7u c\u1ee7a c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng.<\/span><\/p>\n

2. SOD v\u00e0 c\u00e1c b\u1ec7nh vi\u00eam nhi\u1ec5m<\/strong><\/span><\/h3>\n

SOD c\u00f3 th\u1ec3 \u0111\u00f3ng vai tr\u00f2 nh\u01b0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf vi\u00eam qua trung gian b\u1ea1ch c\u1ea7u trung t\u00ednh v\u00e0 c\u00f3 th\u1ec3 l\u00e0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi cho t\u1ed5n th\u01b0\u01a1ng m\u00f4 ph\u1ee5 thu\u1ed9c ROS do b\u1ea1ch c\u1ea7u trung t\u00ednh g\u00e2y ra.<\/span><\/p>\n

C\u00e1c nghi\u00ean c\u1ee9u ti\u1ec1n l\u00e2m s\u00e0ng v\u1edbi Cu, Zn-SOD cho th\u1ea5y k\u1ebft qu\u1ea3 \u0111\u00e1ng kh\u00edch l\u1ec7 trong vi\u1ec7c s\u1eed d\u1ee5ng n\u00f3 nh\u01b0 m\u1ed9t ch\u1ea5t \u0111i\u1ec1u tr\u1ecb cho ng\u01b0\u1eddi trong c\u00e1c t\u00ecnh tr\u1ea1ng vi\u00eam c\u1ea5p t\u00ednh v\u00e0 m\u00e3n t\u00ednh, bao g\u1ed3m b\u1ec7nh da li\u1ec5u, do b\u1ecfng v\u00e0 v\u1ebft th\u01b0\u01a1ng.<\/span><\/p>\n

SOD ngo\u1ea1i b\u00e0o, Mn-SOD v\u00e0 Cu, Zn-SOD \u0111\u00e3 \u0111\u01b0\u1ee3c m\u00f4 t\u1ea3 <\/span>l\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf vi\u00eam ti\u1ec1m n\u0103ng.<\/span><\/p>\n

3. SOD v\u00e0 b\u1ec7nh x\u01a1 nang (cystic fibrosis – CF)<\/strong><\/h3>\n

CF \u0111\u01b0\u1ee3c \u0111\u1eb7c tr\u01b0ng b\u1edfi t\u00ecnh tr\u1ea1ng vi\u00eam m\u00e3n t\u00ednh v\u00e0 s\u1ef1 t\u1eadp trung c\u00e1c b\u1ea1ch c\u1ea7u trung t\u00ednh ho\u1ea1t h\u00f3a. Trong huy\u1ebft t\u01b0\u01a1ng c\u1ee7a b\u1ec7nh nh\u00e2n CF, ho\u1ea1t t\u00ednh SOD th\u1ea5p h\u01a1n \u0111\u00e1ng k\u1ec3 so v\u1edbi nh\u1eefng ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh. H\u01a1n n\u1eefa, trong c\u00e1c t\u1ebf b\u00e0o \u0111\u01a1n nh\u00e2n, \u0111a nh\u00e2n trung t\u00ednh v\u00e0 h\u1ed3ng c\u1ea7u c\u1ee7a b\u1ec7nh nh\u00e2n CF, ho\u1ea1t t\u00ednh Cu, Zn-SOD \u0111\u00e3 b\u1ecb gi\u1ea3m.<\/span><\/p>\n

Ng\u01b0\u1eddi ta \u0111\u00e3 ph\u00e1t hi\u1ec7n ra r\u1eb1ng ho\u1ea1t \u0111\u1ed9ng ch\u1ed1ng t\u1ea1o s\u1ee3i c\u1ee7a Cu, Zn-SOD \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n qua trung gian \u1ee9c ch\u1ebf TGF-B1, sau \u0111\u00f3 l\u00e0 s\u1ef1 \u0111\u1ea3o ng\u01b0\u1ee3c ki\u1ec3u h\u00ecnh c\u1ee7a nguy\u00ean b\u00e0o s\u1ee3i. X\u01a1 h\u00f3a v\u00fa do b\u1ee9c x\u1ea1 gi\u1ea3m \u0111\u00e1ng k\u1ec3 nh\u1edd Cu, Zn-SOD.<\/span><\/p>\n

Nh\u1eefng ph\u00e1t hi\u1ec7n n\u00e0y ch\u1ec9 ra c\u00e1c kh\u1ea3 n\u0103ng \u0111i\u1ec1u tr\u1ecb m\u1edbi nh\u1eafm v\u00e0o c\u00e1c con \u0111\u01b0\u1eddng ch\u1ed1ng oxy h\u00f3a do SOD, nh\u1edd \u0111\u00f3 c\u00f3 th\u1ec3 gi\u1ea3m stress oxy h\u00f3a v\u00e0 qu\u00e1 tr\u00ecnh ch\u1ebft r\u1ee5ng trong t\u1ebf b\u00e0o CF v\u00e0 c\u00f3 th\u1ec3 h\u1ea1n ch\u1ebf ph\u1ea3n \u1ee9ng ti\u1ec1n vi\u00eam<\/span><\/p>\n

4. SOD v\u00e0 thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9<\/strong><\/h3>\n

S\u1ef1 bi\u1ec3u hi\u1ec7n qu\u00e1 m\u1ee9c c\u1ee7a Cu, Zn-SOD l\u00e0m gi\u1ea3m t\u1ed5n th\u01b0\u01a1ng do thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9. Vi\u1ec7c m\u1ea5t Mn-SOD l\u00e0m gi\u1ea3m ti\u1ebfn tri\u1ec3n c\u1ee7a t\u1eafc \u0111\u1ed9ng m\u1ea1ch n\u00e3o t\u1ea1m th\u1eddi sang v\u0129nh vi\u1ec5n. Ph\u01b0\u01a1ng ph\u00e1p b\u1eaft ch\u01b0\u1edbc SOD gi\u00fap ng\u0103n ng\u1eeba suy gi\u1ea3m n\u0103ng l\u01b0\u1ee3ng t\u1ebf b\u00e0o v\u00e0 t\u1ed5n th\u01b0\u01a1ng m\u00f4 li\u00ean quan \u0111\u1ebfn thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 v\u00e0 t\u01b0\u1edbi m\u00e1u.<\/span><\/p>\n

5. SOD v\u00e0 l\u00e3o h\u00f3a<\/strong><\/h3>\n

SOD \u0111\u01b0\u1ee3c coi l\u00e0 m\u1ed9t lo\u1ea1i enzyme ch\u1ed1ng l\u00e3o h\u00f3a. T\u00edch l\u0169y t\u1ed5n th\u01b0\u01a1ng oxy h\u00f3a \u0111\u01b0\u1ee3c coi l\u00e0 m\u1ed9t trong nh\u1eefng c\u01a1 ch\u1ebf ch\u00ednh c\u1ee7a l\u00e3o h\u00f3a. Ng\u01b0\u1eddi ta \u0111\u00e3 g\u1ee3i \u00fd r\u1eb1ng c\u00e1c k\u1ef9 thu\u1eadt b\u1eaft ch\u01b0\u1edbc SOD m\u1edbi c\u00f3 th\u1ec3 h\u1eefu \u00edch trong vi\u1ec7c l\u00e0m gi\u1ea3m c\u00e1c suy gi\u1ea3m nh\u1eadn th\u1ee9c do l\u00e3o h\u00f3a g\u00e2y ra v\u00e0 c\u00e1c kh\u00eda c\u1ea1nh kh\u00e1c c\u1ee7a s\u1ef1 suy gi\u1ea3m sinh l\u00fd do l\u00e3o h\u00f3a.<\/span><\/p>\n

6. SOD v\u00e0 vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p<\/strong><\/span><\/h3>\n

Vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p l\u00e0 m\u1ed9t b\u1ec7nh h\u1ec7 th\u1ed1ng v\u00e0 \u0111\u01b0\u1ee3c \u0111\u1eb7c tr\u01b0ng b\u1edfi ph\u1ea3n \u1ee9ng vi\u00eam m\u00e3n t\u00ednh \u1edf bao ho\u1ea1t d\u1ecbch c\u1ee7a kh\u1edbp, d\u1eabn \u0111\u1ebfn tho\u00e1i h\u00f3a s\u1ee5n v\u00e0 x\u01b0\u01a1ng kh\u1edbp. T\u00ecnh tr\u1ea1ng c\u0103ng th\u1eb3ng oxy h\u00f3a gia t\u0103ng ho\u1eb7c t\u00ecnh tr\u1ea1ng thi\u1ebfu h\u1ee5t ch\u1ea5t ch\u1ed1ng oxy h\u00f3a l\u00e0 r\u1ea5t quan tr\u1ecdng trong c\u01a1 ch\u1ebf b\u1ec7nh sinh c\u1ee7a b\u1ec7nh n\u00e0y.<\/span><\/p>\n

M\u1ed9t s\u1ed1 ch\u1ea5t ch\u1ed1ng oxy h\u00f3a bao g\u1ed3m SOD v\u00e0 Vitamin E c\u00f3 vai tr\u00f2 ch\u1ed1ng vi\u00eam trong b\u1ec7nh vi\u00eam kh\u1edbp. Ng\u01b0\u1eddi ta th\u1ea5y r\u1eb1ng ho\u1ea1t t\u00ednh c\u1ee7a SOD th\u1ea5p \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p v\u00e0 vi\u1ec7c s\u1eed d\u1ee5ng SOD c\u00f3 t\u00e1c d\u1ee5ng t\u00edch c\u1ef1c trong \u0111i\u1ec1u tr\u1ecb vi\u00eam kh\u1edbp th\u1ef1c nghi\u1ec7m.<\/span><\/p>\n

7. SOD v\u00e0 c\u00e1c b\u1ec7nh tho\u00e1i h\u00f3a th\u1ea7n kinh<\/strong><\/h3>\n

Stress oxy h\u00f3a \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 c\u00f3 li\u00ean quan \u0111\u1ebfn sinh l\u00fd b\u1ec7nh c\u1ee7a m\u1ed9t s\u1ed1 b\u1ec7nh tho\u00e1i h\u00f3a th\u1ea7n kinh. C\u00f3 s\u1ef1 gi\u1ea3m ho\u1ea1t \u0111\u1ed9ng c\u1ee7a c\u00e1c enzym ch\u1ed1ng oxy h\u00f3a nh\u01b0 SOD, catalase v\u00e0 glutathione peroxidase \u1edf c\u00e1c v\u00f9ng t\u1ed5n th\u01b0\u01a1ng c\u1ee7a b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh Alzheimer (AD).<\/span><\/p>\n

Ngo\u00e0i ra, Cu, Zn-SOD l\u00e0 m\u1ed9t trong nh\u1eefng n\u1ea1n nh\u00e2n ch\u00ednh c\u1ee7a qu\u00e1 tr\u00ecnh oxy h\u00f3a g\u00e2y t\u1ed5n th\u01b0\u01a1ng n\u00e3o trong b\u1ec7nh AD v\u00e0 b\u1ec7nh Parkinson. Th\u1ef1c nghi\u1ec7m \u0111\u00e3 ch\u1ee9ng minh r\u1eb1ng s\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a SOD-2 l\u00e0m gi\u1ea3m super-oxide h\u1ed3i h\u1ea3i m\u00e3 v\u00e0 do \u0111\u00f3 ng\u0103n ng\u1eeba s\u1ef1 thi\u1ebfu h\u1ee5t b\u1ed9 nh\u1edb \u1edf m\u00f4 h\u00ecnh chu\u1ed9t AD. B\u1ed5 sung SOD cho th\u1ea5y s\u1ef1 c\u1ea3i thi\u1ec7n \u1edf m\u00f4 h\u00ecnh chu\u1ed9t AD.<\/span><\/p>\n

SOD\/Catalase mimetic EUK-207 th\u1ec3 hi\u1ec7n kh\u1ea3 n\u0103ng b\u1ea3o v\u1ec7 ch\u1ed1ng l\u1ea1i v\u00e0 l\u00e0m gi\u00e1n \u0111o\u1ea1n s\u1ef1 ti\u1ebfn tri\u1ec3n c\u1ee7a b\u1ec7nh l\u00fd tho\u00e1i h\u00f3a th\u1ea7n kinh c\u0169ng nh\u01b0 suy gi\u1ea3m nh\u1eadn th\u1ee9c \u1edf m\u00f4 h\u00ecnh chu\u1ed9t AD.<\/span><\/p>\n

8. SOD v\u00e0 b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng<\/strong><\/h3>\n

T\u0103ng c\u0103ng th\u1eb3ng oxy h\u00f3a \u0111\u00f3ng m\u1ed9t vai tr\u00f2 quan tr\u1ecdng trong c\u0103n nguy\u00ean c\u1ee7a b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng v\u00e0 c\u00e1c bi\u1ebfn ch\u1ee9ng c\u1ee7a n\u00f3. Trong b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng, t\u0103ng \u0111\u01b0\u1eddng huy\u1ebft dai d\u1eb3ng k\u00edch th\u00edch s\u1ea3n xu\u1ea5t ROS t\u1eeb nhi\u1ec1u ngu\u1ed3n kh\u00e1c nhau. K\u1ebft qu\u1ea3 l\u00e0, b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng th\u01b0\u1eddng d\u1eabn \u0111\u1ebfn t\u0103ng h\u00ecnh th\u00e0nh ROS v\u00e0 suy y\u1ebfu kh\u1ea3 n\u0103ng ph\u00f2ng th\u1ee7 ch\u1ed1ng oxy h\u00f3a.<\/span><\/p>\n

\u0110i\u1ec1u tr\u1ecb b\u1eb1ng SOD \u0111\u00e3 \u0111\u01b0\u1ee3c th\u1ef1c nghi\u1ec7m ch\u1ee9ng minh l\u00e0 l\u00e0m gi\u1ea3m c\u0103ng th\u1eb3ng oxy h\u00f3a gan \u1edf \u0111\u1ed9ng v\u1eadt m\u1eafc b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng. SOD mimetic \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng th\u00e0nh c\u00f4ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng \u1edf chu\u1ed9t m\u1eafc b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng. SOD \u0111\u01b0\u1ee3c bi\u1ebfn \u0111\u1ed5i v\u1ec1 m\u1eb7t h\u00f3a h\u1ecdc c\u00f3 hi\u1ec7u qu\u1ea3 trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng v\u00e0 mang l\u1ea1i l\u1ee3i \u00edch \u0111i\u1ec1u tr\u1ecb trong s\u1eed d\u1ee5ng l\u00e2m s\u00e0ng. N\u00f3 \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh r\u1eb1ng SOD ngo\u1ea1i b\u00e0o c\u00f3 th\u1ec3 ho\u1ea1t \u0111\u1ed9ng nh\u01b0 m\u1ed9t t\u00e1c nh\u00e2n \u0111i\u1ec1u tr\u1ecb \u0111\u1ec3 b\u1ea3o v\u1ec7 s\u1ef1 ti\u1ebfn tri\u1ec3n c\u1ee7a b\u1ec7nh th\u1eadn do \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng<\/span><\/p>\n

K\u1ebft lu\u1eadn c\u1ee7a nghi\u00ean c\u1ee9u:<\/strong><\/span><\/p>\n

1. SOD c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng nh\u01b0 m\u1ed9t lo\u1ea1i d\u01b0\u1ee3c ph\u1ea9m \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh kh\u00e1c nhau do qu\u00e1 tr\u00ecnh oxy h\u00f3a g\u00e2y ra.<\/em><\/strong><\/span><\/p>\n

2. C\u00e1c nghi\u00ean c\u1ee9u trong t\u01b0\u01a1ng lai v\u1ec1 SOD s\u1ebd t\u1eadp trung h\u01b0\u1edbng \u0111\u1ebfn b\u1ec7nh nh\u00e2n.<\/em><\/strong><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

SOD l\u00e0 m\u1ed9t lo\u1ea1i Enzym ch\u1ed1ng oxy h\u00f3a c\u00f3 trong t\u1ea5t c\u1ea3 c\u00e1c t\u1ebf b\u00e0o s\u1ed1ng trong c\u01a1 th\u1ec3. N\u00f3 \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c gi\u1ea3m stress oxy h\u00f3a.\u00a0SOD c\u00f3…<\/p>\n","protected":false},"author":1,"featured_media":462,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[29,6,26,5,7,27],"tags":[],"class_list":["post-420","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-aqua-sod-probiotics","category-lam-dep","category-rejuve","category-suc-khoe","category-tre-hoa","category-ung-thu"],"yoast_head":"\nSOD l\u00e0 g\u00ec? - Ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe b\u1eaft \u0111\u1ea7u t\u1eeb t\u1ebf b\u00e0o<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/calerievn.com\/index.php\/2023\/08\/06\/sod-la-gi\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"SOD l\u00e0 g\u00ec? - Ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe b\u1eaft \u0111\u1ea7u t\u1eeb t\u1ebf b\u00e0o\" \/>\n<meta property=\"og:description\" content=\"SOD l\u00e0 m\u1ed9t lo\u1ea1i Enzym ch\u1ed1ng oxy h\u00f3a c\u00f3 trong t\u1ea5t c\u1ea3 c\u00e1c t\u1ebf b\u00e0o s\u1ed1ng trong c\u01a1 th\u1ec3. N\u00f3 \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c gi\u1ea3m stress oxy h\u00f3a.\u00a0SOD c\u00f3...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/calerievn.com\/index.php\/2023\/08\/06\/sod-la-gi\/\" \/>\n<meta property=\"og:site_name\" content=\"Ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe b\u1eaft \u0111\u1ea7u t\u1eeb t\u1ebf b\u00e0o\" \/>\n<meta property=\"article:published_time\" content=\"2023-08-06T00:50:16+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-12-17T15:07:50+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/calerievn.com\/wp-content\/uploads\/2023\/08\/SOD.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"1270\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u0110\u01b0\u1ee3c vi\u1ebft b\u1edfi\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u01af\u1edbc t\u00ednh th\u1eddi gian \u0111\u1ecdc\" \/>\n\t<meta name=\"twitter:data2\" content=\"9 ph\u00fat\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/calerievn.com\/index.php\/2023\/08\/06\/sod-la-gi\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/calerievn.com\/index.php\/2023\/08\/06\/sod-la-gi\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/calerievn.com\/#\/schema\/person\/d3fd86102c134af6b143611f656f69ff\"},\"headline\":\"SOD l\u00e0 g\u00ec?\",\"datePublished\":\"2023-08-06T00:50:16+00:00\",\"dateModified\":\"2024-12-17T15:07:50+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/calerievn.com\/index.php\/2023\/08\/06\/sod-la-gi\/\"},\"wordCount\":2358,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/calerievn.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/calerievn.com\/index.php\/2023\/08\/06\/sod-la-gi\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/calerievn.com\/wp-content\/uploads\/2023\/08\/SOD.png\",\"articleSection\":[\"Aqua SOD Probiotics\",\"L\u00e0m \u0110\u1eb9p\",\"Rejuve\",\"S\u1ee9c Kh\u1ecfe\",\"Tr\u1ebb h\u00f3a\",\"Ung th\u01b0\"],\"inLanguage\":\"vi\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/calerievn.com\/index.php\/2023\/08\/06\/sod-la-gi\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/calerievn.com\/index.php\/2023\/08\/06\/sod-la-gi\/\",\"url\":\"https:\/\/calerievn.com\/index.php\/2023\/08\/06\/sod-la-gi\/\",\"name\":\"SOD l\u00e0 g\u00ec? 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